Age dynamics of cell populations and mast cell density in human bronchial mucosa

Using the quantitative analysis of mast cell number and granularity, some regularities of their age-associated dynamics were established. In suckling babies and in early childhood the mast cells are small and contain a moderate amount of secretory granules with no signs of degranulation. Henceforth they become larger and are functioning asynchronously. Mast cell number increases up to the age of 16 years. After 36 years mast cell prevalence and their secretory granule content are reduced.