Glioblastoma in multiple sclerosis: a case report |
| |
| Authors: | Giovanni Frisullo Agata Katia Patanella Viviana Nociti Alessandro Cianfoni Raffaele Iorio Assunta Bianco Alessandro Marti Pietro Attilio Tonali Anna Paola Batocchi |
| |
| Affiliation: | (1) Department of Neuroscience, Institute of Neurology, Catholic University, Largo Agostino Gemelli, 8, 00168 Rome, Italy;(2) Fondazione Don Gnocchi, Rome, Italy;(3) Department of Radiology, Neuroradiology Section, MUSC – Medical University of South Carolina, Charleston, SC, USA |
| |
| Abstract: | Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases. |
| |
| Keywords: | Glioblastoma multiforme Multiple sclerosis Transcription factors Differential diagnosis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
