| 解耦联蛋白2的主要生理功能及研究进展 |
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| 引用本文： | 邵雪,高继东. 解耦联蛋白2的主要生理功能及研究进展[J]. 医学综述, 2009, 15(24): 3718-3720 |
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| 作者姓名： | 邵雪 高继东 |
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| 作者单位： | 1. 青海大学医学院,西宁,810001
2. 青海大学附属医院内分泌科,西宁,810001 |
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| 摘 要： | 解耦联蛋白2是位于线粒体内膜上的转运蛋白,广泛存在于骨骼肌、心脏、肝、肾、胰等多种组织中。解耦联蛋白2参与能量代谢、凋亡、活性氧的生成等过程,并同非酒精性脂肪肝、动脉粥样硬化、局部缺血以及缺血再灌注损伤、肥胖及2型糖尿病等有着密切的关系,故引起人们的广泛重视。本研究对解耦联蛋白2的主要生理功能及研究进展予以综述。
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| 关 键 词： | 解耦联蛋白2 生理功能 能量代谢 |
Research Progress on Physiological Function of Uncoupling Protein |
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| SHAO Xue,GAO Ji-dong. Research Progress on Physiological Function of Uncoupling Protein[J]. Medical Recapitulate, 2009, 15(24): 3718-3720 |
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| Authors: | SHAO Xue GAO Ji-dong |
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| Affiliation: | SHAO Xue , GAO Ji-dong(1. Qinghai University, School of Medicine ,Xining 810001, China; 2. Department of Endocrinology, Qinghai University Affiliated Hospital ,Xining 810001 , China) |
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| Abstract: | Uncoupling protein 2 （UCP2） is a new member of superfamily of transport protein in the mitochondrial inner membrane. UCP2 is expressed in a wide range of tissues and organs. It partieipates in the process of energy metabolism, apoptosis, and production of ROS. UCP2 has close relationship with nonalcoholic fatty liver,atherosclerosis,isehemia,isehemia-reperfusion injury,obesity and diabetes mellitus. This article maainly expounded physiologic function of UCP2 and its research progress. |
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| Keywords: | Uncoupling protein 2 Physiological function Energy metabolism |
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