Dissolution of human gallstone with clofibrate

We have studied the effect of different concentrations of clofibrate upon biliary cholesterol calculi. We have seen that all the calculi have completely dissolved within the first 25 days after being placed in contact with the clofibrate solution. The rate of dissolution of the calculi was directly proportional to the concentration of clofibrate in the solution used. With 1500 mg of clofibrate in the solution, the calculi were completely dissolved within 15 days.It is our wish to communicate these results obtained with the utilization of clofibrate as a new solvent and to emphasize that clofibrate possesses a greater litholitic capacity than any of the other substances discovered so far. We also wish to stress that clofibrate does not possess undesirable sideeffects.