| 不同剂量雷公藤多苷治疗肾移植后蛋白尿临床研究 |
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| 引用本文： | 黄云,龙田彪,詹峰,潘楚瑛,陈道军,林书典. 不同剂量雷公藤多苷治疗肾移植后蛋白尿临床研究[J]. 南方医科大学学报, 2008, 28(12): 2269-2271 |
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| 作者姓名： | 黄云 龙田彪 詹峰 潘楚瑛 陈道军 林书典 |
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| 作者单位： | 海南省人民医院肾内科,海南,海口,570311 |
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| 摘 要： | 目的 观察不同剂量雷公藤多苷治疗肾移植术后蛋白尿的临床效果.方法 选择肾移植术后出现蛋白尿患者45例,按随机数字法分为3组,足量雷公藤多苷组(常规组)、半量雷公藤多苷组(半量组)、对照组各15例.常规组在应用免疫抑制剂基础上用雷公藤多苷1 mg/(kg·d)治疗.半量组在应用免疫制剂基础上用雷公藤多苷0.5 mg/(kg·d)治疗,对照组应用免疫抑制剂.观察三组患者治疗后24h尿蛋白定量、尿素氮、肌酐、环孢素用量及副作用.结果 常规组、半量组均能明显减少蛋白尿,24h蛋白定量均低于对照组(P<0.05).常规组、半量组患者环孢素用量低于对照组(P<0.05).半量组副作用低于常规组.结论 雷公藤多苷能明显减少肾移植术后出现蛋白尿患者的蛋白尿.达到保护移植肾肾功能及减少环孢素用量.长期应用半量雷公藤多苷能达到常规雷公藤多苷相同治疗效果,副作用轻.
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| 关 键 词： | 肾移植 不同剂量 雷公藤多苷 蛋白尿 |
Therapeutic effect of Tripterygium wilfordii multiglycosides on proteinuria in kidney transplant recipients |
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| HUANG Yun,LONG Tian-biao,ZHAN Feng,PAN Chu-ying,CHEN Dao-jun,LIN Shu-dian. Therapeutic effect of Tripterygium wilfordii multiglycosides on proteinuria in kidney transplant recipients[J]. Journal of Southern Medical University, 2008, 28(12): 2269-2271 |
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| Authors: | HUANG Yun LONG Tian-biao ZHAN Feng PAN Chu-ying CHEN Dao-jun LIN Shu-dian |
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| Affiliation: | HUANG Yun,LONG Tian-biao,ZHAN Feng,PAN Chu-ying,CHEN Dao-jun,LIN Shu-dian Department of Nephropathy,Hainan Provincial People's Hospital,Haikou 570311,China |
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| Abstract: | Objective To study the effect of multiglycosides of Tripterygium wilfordii (MTW) for treatment of proteinuria in kidney transplant recipients. Methods Forty-five kidney transplant recipients with proternuria were randomized into 3 groups (n=15) and received full daily dose (1 mg/kg) MTW, half dose (0.5 mg/kg) MTW or no MTW (control) in addition to immunosuppressant therapy. The 24-hour urinary protein (24 h Upro), blood urea nitrogen (BUN), serum creatinine (Scr), dose of ciclosporin and the adverse effects... |
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| Keywords: | kidney transplant multiglycosides Tripterygium wilfordii proteinuria various doses |
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