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| 肝豆状核变性患者肝脏剪切波速度的变化 | |
| 引用本文： | 齐端,唐绘卓,阳静,欧阳飞. 肝豆状核变性患者肝脏剪切波速度的变化[J]. 实用肝脏病杂志, 2021, 24(2): 168-171. DOI: 10.3969/j.issn.1672-5069.2021.02.005 |
| 作者姓名： | 齐端 唐绘卓 阳静 欧阳飞 |
| 作者单位： | 423000 湖南省郴州市第四人民医院超声科(齐端); 郴州市第一人民医院儿童呼吸一区(唐绘卓); 北院儿童保健科(欧阳飞); 南华大学附属第一医院消化内科(阳静) |
| 基金项目： | 湖南省郴州市科技计划项目(编号:2011-53)。 |
| 摘 要： | 目的 采用超声声辐射力脉冲成像(ARFI)技术检测肝豆状核变性(HLD)患者肝脏剪切波速度(SWV)的变化.方法 2017年6月～2019年6月我院收治的38例HLD患者、49例非HLD的慢性肝脏疾病患者和56例健康体检者,采用超声观察肝脏表现,并应用ARFI技术测量肝脏SWV.采用原子吸收光谱法测定血清铜离子(Cu2... |
| 关 键 词： | 肝豆状核变性 声辐射力脉冲成像 剪切波速度 |
| 收稿时间： | 2020-08-18 |
Shear wave velocity by acoustic radiation force impulse in patients with hepatolenticular degeneration |
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| Qi Duan,Tang Huizhuo,Yang Jing,et. Shear wave velocity by acoustic radiation force impulse in patients with hepatolenticular degeneration[J]. Journal of Clinical Hepatology, 2021, 24(2): 168-171. DOI: 10.3969/j.issn.1672-5069.2021.02.005 | |
| Authors: | Qi Duan Tang Huizhuo Yang Jing et |
| Affiliation: | Department of Ultrasound, Fourth People's Hospital, Chenzhou 423000,Hunan Province, China |
| Abstract: | Objective The purpose of this study was to observe the shear wave velocity(SWV)by acoustic radiation force impulse(ARFI)in patients with hepatolenticular degeneration(HLD).Methods 38 patients with HLD,49 with other chronic liver disease(CLD)and 56 healthy persons were recruited in thisstudy between June 2017and June 2019.The ARFI technology was used to measure hepatic SWV.Serum copper ion(Cu2+)level was determined by atomic absorption spectrometry,serum ceruloplasmin(CP)level was determined by immunoturbidimetric method,and serum copper oxidase(sCO)were determined by manual method.Serum type Ⅲ procollagen(PC-Ⅲ),laminin(LN),type Ⅳ collagen(Ⅳ-C),and hyaluronic acid(HA)wereassayed by radioimmunoassay.Results Serum Cu2+and CP levels in patients with HLD were(6.7±1.5)μmol/L and(88.0±13.2)mg/L,significantly lower than【(13.2±1.6)μmol/L and(216.6±43.5)mg/L,respectively,P<0.05】in patients with CLD,or【(17.2±6.2)μmol/L and(400.0±150.0)mg/L,respectively,P<0.05】in healthy persons,and sCO activity in patients with HLD was(0.02±0.01)U/L,much lower than【(0.4±0.1)U/L,P<0.05】in healthy persons;serum PC-Ⅲ,Ⅳ-C,LN and HA levels in patients with HLD were(11.1±0.3)ng/mL,(95.9±12.4)ng/mL,(43.6±11.4)ng/mL and(88.9±15.8)ng/mL,all significantly lower than【(48.5±24.2)ng/mL,(140.6±15.3)ng/mL,(847.6±38.5)ng/mL and(261.2±22.8)ng/mL,P<0.05】in patients with CLD;the sonogram showed that the liver were fatty liver-like,starlight,dendritic,terraneous or nodular in patients with HLD,and the SWV in patients with HLD was(1.9±0.2)m/s,significantly lower than【(2.2±0.3)m/s,P<0.05】in patients with CLD,but much higher than【(1.1±0.2)m/s,P<0.05】in healthy persons.Conclusion The sonogram shows characteristic hepatic changes in patients with HLD,and the SWV might help discriminate with other CLD to some extent. |
| Keywords: | Hepatolenticular degeneration Acoustic radiation force impulse Shear wave velocity |
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