脑出血术后高压氧治疗时机及并发应激性溃疡出血的临床研究

目的 探讨高压氧治疗高血压基底核区脑出血术后患者应激性溃疡出血的发生率及治疗时机对预后的影响.方法 将586例患者随机分为3组,A组:对照组;B组:术后7～14 d开始高压氧治疗;C组:术后15～30 d开始高压氧治疗.随访6个月,比较3组患者应激性溃疡出血的发生率及日常生活活动能力量表(ADL)评分.结果 术后7～14 d,B组与A组、C组比较,应激性溃疡出血的发生率间差异均有统计学意义(P＜0.01).术后15～30 d,C组与A组应激性溃疡出血的发生率间差异有统计学意义(P＜0.01).A、B、C 3组存活患者随访6个月时ADL评分分别为(45.7±28.8)分、(78.7±22.8)分和(62.8±28.9)分,差异有统计学意义(F=52.885,P＜0.05),A组与B组、B组与C组、C组与A组比较,差异均有统计学意义(q=-33.008,P＜0.01;q=15.893,P＜0.01;q=17.115,P＜0.01).3组患者随访6个月时ADL评分等级间差异有统计学意义(H=69.064,P＜0.05).结论 高血压基底核区脑出血术后患者的高压氧治疗应尽早进行,以术后7～14 d开始治疗疗效最好,虽增加应激性溃疡出血的发生率,但并不影响高压氧治疗的疗效,可明显降低致残率.

Timing of Postoperative Hyperbaric Oxygen Therapy in Patients with Hypertensive Intracerebral Haemorrhage and Its Impact on Complicated Stress Ulcer Bleeding

Objective To discuss the correlations between postoperative hyperbaric oxygen therapy for hypertensive basal ganglia intracerebral haemorrhage and complicated stress ulcer bleeding and to explore the impact of treatment timing on prognosis.Methods A total of 586 postoperative patients with hypertensive basal ganglia intracerebral haemorrhage were randomly assigned to group A(control group),group B(hyperbaric oxygen therapy was carried out 7~14 days after operation),and group C(hyperbaric oxygen therapy was ...