幽门螺杆菌三联根除疗法影响因素的Logistic回归分析

目的 探讨幽门螺杆菌(H.pylori)的耐药性、患者的性别、年龄、烟酒史、疾病类型及组织学改变等对H.pylori根除率的影响.方法 选取78例十二指肠溃疡(DU)或非溃疡性消化不良(NUD)患者,所有患者接受7 d的H.pylori根除治疗.治疗结束后,采用14C-尿素呼气试验评估H.pylori根除情况.H.pylori药敏试验采用纸片法和二倍平皿稀释法.结果 78例患者均分离出78株革兰阴性弯曲海鸥状弧形杆菌,其中14.1%对克拉霉素原发性耐药,69.2%对甲硝唑耐药,1.3%对阿莫西林耐药.Loginstic回归分析显示,患者性别、克拉霉素耐药的OR值分别为5.649[95%CI(1.3,24.6)]和8.520[95%CI(1.62,44.7)],与H.pylori根除呈正相关(P＜0.05);DU的OR=0.119[95%CI (0.018,0.072)],与H.pylori根除呈负相关(P＜0.05).结论 克拉霉素耐药、DU、患者的性别是影响H.pylori根除的相关独立因素.

Logistic Regression Analysis on Influencing Factors of Helicobacter Pylori Infection Eradication with Triple Therapy

Objective To investigate the impact of drug resistance,sex,age,smoking and drinking habit,disease types,and histological changes on eradication rate of Helicobacter pylori(H.pylori).Methods A total of 78 patients with duodenal ulcer and non-ulcer dyspepsia were recruited and treated with a 7-day eradication plan.14C test was employed to evaluate effects of H.pylori eradication.For drug sensitive test of H.pylori we adopted paper disk method and double plating dilution method.Results A total of 78 G-Campylob...