Immunohistochemical,ultrastructural and biochemical studies of an amylase-producing breast carcinoma |
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| Authors: | Hideo Inaji Hiroki Koyama Masahiko Higashiyama Shinzaburo Noguchi Hitoshi Yamamoto Osamu Ishikawa Kaoru Omichi Takeshi Iwanaga Akira Wada |
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| Affiliation: | (1) Departments of Surgery, The Center for Adult Diseases, Osaka, 3-3 Nakamichi 1-chome, Higashinari-ku, 537 Osaka, Japan;(2) Department of Pathology, The Center for Adult Diseases, Osaka, 3-3 Nakamichi 1-chome, Higashinari-ku, 537 Osaka, Japan;(3) Department of Chemistry, Osaka University College of Science, Toyonaka, 560 Osaka, Japan |
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| Abstract: | ![]()
Summary We describe a breast cancer with ectopic production of amylase, found in the patient's serum, urine and in the tumour. Clinically, serum amylase levels reflected both the progression of the disease and regression induced by various therapies. Using agarose gel electrophoresis and a wheat protein inhibitor assay, the predominant serum amylase appeared to be identical to pancreatic-type isoenzyme. However, the action mode analysis using a new fluorogenic substrate revealed that the serum contained non-salivary, non-pancreatic amylase. The tumour had microscopic features of invasive ductal carcinoma with some argyrophilic differentiation. The component cells stained positively for amylase, and ultrastructurally numerous secretory granules were seen. |
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| Keywords: | Breast carcinoma Ectopic amylase production Non-salivary, non-pancreatic amylase Argyrophilia |
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