银杏达莫联合甲钴胺治疗糖尿病周围神经病变

观察银杏达莫联合甲钴胺治疗糖尿病周围神经病变（DPN）的临床疗效。方法对102例DPN患者进行随机对照观察，治疗组50例，对照组52例。治疗组予以银杏达莫和甲钴胺治疗，对照组单用甲钴胺治疗，连用4周。观察两组患者治疗前后症状和体征变化，检测正中神经、尺神经及腓神经的运动神经传导速度（MNCV）和感觉神经传导速度（SNCV）。结果治疗组的DPN症状、体征较对照组明显改善（x。=10．090，P〈0．01），治疗组治疗后正中神经、尺神经及腓神经的MNCV分别为（49．12±3．32）m／s、（52．1I±3．12）rrds、（47．32±3．21）m／s，较对照组有显著改善（t=3．517、13．204、3．968，均P〈O．05）；正中神经、尺神经及腓神经的SNCV分别为（47．13±2．56）m／s、（55．12±2．31）m／s、（46．78±2．66）m／s，较对照组有显著改善（t=3．653、17．990、4．348，均P〈0．05）。结论银杏达莫联合甲钴胺治疗DPN，疗效优于单用甲钴胺，且安全有效，值得临床推广。

Case-control study on ginkgo-dipyridimolum and mecobalamin for treatment diabetic peripheral neuropathy

Objective To observe the effect of the combined therapy of ginkgo-dipyridimolum and mecobalamin for diabetic peripheral neuropathy (DPN).Methods A total of 102 DPN cases were randomly divided into treatment group(n =50) and control group(n =52).The treatment group was given ginkgo-dipyridimolum and mecobalamin, and the control group was given only mecobalamin for 4 weeks.We observed the change of symptom and sign of both groups before and after treatment,and the MNCV and SNCV of median nerve,ulnar nerve and peroneal nerve were detected.Results In the treatment group, the improvement of DPN symptoms (x2 = 10.090, P ＜ 0.01) and nervous conducting speed were much more obvious than that in the control group(MNCV of median nerve, ulnar nerve and peroneal nerve was(49.12 ± 3.32) m/s, (52.11 ± 3.12) m/s and(47.32 ± 3.21) m/s respectively; SNCV of median nerve,ulnar nerve and peroneal nerve was(47.13 ± 2.56) m/s, (55.12 ± 2.31) m/s, (46.78 ± 2.66) m/s respectively,all P ＜0.05).Conclusion The combined therapy of ginkgo-dipyridimolum and mecobalamin could effectively improve the therapeutic outcome of DPN, and the treatment was safe and worthy of widespread use.