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| c-erbB-2基因在乳腺浸润性导管癌及腋窝转移淋巴结中的表达相关性分析 | |
| 引用本文： | 王晔,宋科瑛,王建丰,仇生龙,项富海,李克. c-erbB-2基因在乳腺浸润性导管癌及腋窝转移淋巴结中的表达相关性分析[J]. 中国现代普通外科进展, 2009, 12(2) |
| 作者姓名： | 王晔 宋科瑛 王建丰 仇生龙 项富海 李克 |
| 作者单位： | 上海交通大学附属第一人民医院普外科,上海,200080 |
| 摘 要： | 目的:探讨乳腺浸润性导管癌中c-erbB-2的表达及其与腋窝淋巴结等临床病理因素的相关性.方法:采用免疫组织化学方法检测149例乳腺浸润性导管癌患者乳腺原发灶及47例腋淋巴结转移灶中c-erbB-2的表达,结合临床病理因素,分析其相关性.结果:19.46%(29/149)原发灶c-erbB-2高表达,其表达水平与肿瘤大小、腋窝淋巴结转移情况呈正相关,与ER、PR表达呈负相关.47例腋窝淋巴结转移乳腺浸润性导管癌患者中,原发灶c-erbB-2高表达18例(38.30%),腋窝淋巴结转移灶c-erbB-2高表达16例(34.04%),两者差异无统计学意义(P>0.05).5例原发灶c-erbB-2阴性或低表达患者腋窝淋巴结转移呈高表达,7例原发灶c-erbB-2高表达患者淋巴结转移呈阴性或低表达,变化率为25.53%(12/47).结论: c-erbB-2可以作为预测乳腺癌预后的指标,指导术后治疗,但应当考虑c-erbB-2在原发灶和复发转移灶之间的差异,有必要对复发转移灶进行c-erbB-2检测. |
| 关 键 词： | 乳腺肿瘤·癌基因 c-erbB-2·肿瘤转移 |
Expression of oncogene c-erbB-2 and its relationship with clinicopathologic factors in infiltrating ductal breast cancer and metastatic axillary lymph nodes |
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| WANG Ye,SONG Ke-ying,WANG Jian-fen,QIU Sheng-long,XIANG Fu-hai,LI Ke. Expression of oncogene c-erbB-2 and its relationship with clinicopathologic factors in infiltrating ductal breast cancer and metastatic axillary lymph nodes[J]. Chinese Journal of Current Advances in General Surgery, 2009, 12(2) | |
| Authors: | WANG Ye SONG Ke-ying WANG Jian-fen QIU Sheng-long XIANG Fu-hai LI Ke |
| Affiliation: | lShanghai 200080;China |
| Abstract: | Objective:To observe the expression of c-erbB-2 and its relationship with clinical and pathological characteristics in infiltrating ductal breast cancer. Methods: Immunohisto-chemical technique was performed to detect the expression of oncogene c-erbB-2 in 149 cases of primary carcinoma and 47 cases of synchronous metastatic lymph node. Their clinical and pathological indices and follow up data were analyzed. Results: The overexpression rate of c-erbB-2 was 19.46%(29/149). The expression of c-erbB-2 was sig... |
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