| 顶空气相色谱法测定盐酸格拉司琼中硫酸二甲酯残留量 |
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| 引用本文： | 邓桂凤,姚彤炜. 顶空气相色谱法测定盐酸格拉司琼中硫酸二甲酯残留量[J]. 浙江大学学报(医学版), 2008, 37(2): 156-158. DOI: 10.3785/j.issn.1008-9292.2008.02.009 |
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| 作者姓名： | 邓桂凤 姚彤炜 |
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| 作者单位： | 浙江大学药学院药物分析与药物代谢研究室,浙江,杭州,310058 |
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| 摘 要： | 目的建立盐酸格拉司琼中硫酸二甲酯残留量的测定法.方法采用顶空气相色谱法,载气为氮气,FID检测器,色谱柱为Angilent INNOWAX毛细管柱,柱温50℃,单点对照法检测盐酸格拉司琼中硫酸二甲酯的含量.结果盐酸格拉斯琼中硫酸二甲酯未检出.且在同一色谱条件下,硫酸二甲酯的保留时间与可能存在的其它残留溶剂乙醇、乙酸乙酯、异丙醇、二氯甲烷和氯仿等的保留时间不同,方法的专属性良好;测得硫酸二甲酯的检出限为0.0016%.结论建立的方法能有效控制盐酸格拉司琼中硫酸二甲酯的残留量.
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| 关 键 词： | 格兰塞隆/分析 色谱法 气相 药物残留物/分析 盐酸格拉司琼 有机溶剂残留量 硫酸二甲酯 顶空气 色谱法测定 盐酸 格拉司 琼中 硫酸二甲酯 残留量 gas chromatography granisetron hydrochloride residual sulphate 控制 专属性 氯仿 二氯甲烷 异丙醇 乙酸乙酯 乙醇 残留溶剂 存在 |
| 文章编号： | 1008-9292(2008)02-0156-03 |
| 修稿时间： | 2007-12-14 |
Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography |
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| DENG Gui-feng,YAO Tong-wei. Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography[J]. Journal of Zhejiang University. Medical sciences, 2008, 37(2): 156-158. DOI: 10.3785/j.issn.1008-9292.2008.02.009 |
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| Authors: | DENG Gui-feng YAO Tong-wei |
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| Affiliation: | Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. |
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| Abstract: | OBJECTIVE: To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride. METHODS: An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature. RESULT: Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%. CONCLUSION: The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride. |
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| Keywords: | Granisetron/anal Chromatography gas Drug residues/anal Granisetron hydrochloride Residual solvent Dimethyl sulphate |
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