| 左卡尼汀改善非糖尿病维持性血液透析患者胰岛素抵抗 |
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| 引用本文： | 张必嘏,郭黎莉.左卡尼汀改善非糖尿病维持性血液透析患者胰岛素抵抗[J].中国血液净化,2010,9(2):94-96. |
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| 作者姓名： | 张必嘏 郭黎莉 |
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| 作者单位： | 上海交通大学附属上海市第一人民医院宝山分院血液净化中心,上海,200940 |
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| 摘 要： | 目的探讨左卡尼汀对非糖尿病维持性血液透析(HD)患者胰岛素抵抗的影响。方法41例非糖尿病HD患者为研究对象,20例应用左卡尼汀治疗,另21例作为对照组。治疗方法为静脉注射左卡尼汀(雷卡)1.0g、每次透析结束后静脉注射,观察时间6月。观察指标包括空腹血糖、胰岛素、胰岛素抵抗指数(HOMA-IR)和炎症标志物血C反应蛋白(CRP)。结果左卡尼汀治疗6月后,治疗组和对照组空腹血糖无变化,而在治疗组空腹胰岛素和HOMA-IR明显下降,下降差值分别为-10(-35,20)vs-1(-15,20),P=0.03;(-2.8±0.6)vs(-0.4±0.5),P0.01。血CRP在治疗组明显下降,下降差值为(-5.9±1.2)vs(-0.1±0.1)(对照组),P0.01。相关分析显示,血CRP与空腹胰岛素(r=0.56,P0.01)和HOMA-IR(r=0.46,P0.05)呈正相关。结论静脉注射左卡尼汀治疗有效改善非糖尿病HD患者胰岛素抵抗,改善的胰岛素抵抗与改善炎症状态有关,我们的结果对HD患者胰岛素抵抗的治疗提供新的治疗思路。
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| 关 键 词： | 血液透析（HD） 左卡尼汀 胰岛素抵抗 C反应蛋白 |
L-carnitine supplementation improves insulin resistance in non-diabetic patients on hemodialysis |
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| Zhang Bi-Gu,Guo Li-Li.Hemodialysis center,Bao Shan Brach of Shanghai No. People\' Hospital,Shanghai Jiao Tong University,Shanghai ,China.L-carnitine supplementation improves insulin resistance in non-diabetic patients on hemodialysis[J].Chinese Journal of Blood Purification,2010,9(2):94-96. |
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| Authors: | Zhang Bi-Gu Guo Li-LiHemodialysis center Bao Shan Brach of Shanghai No People\' Hospital Shanghai Jiao Tong University Shanghai China |
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| Institution: | Zhang Bi-Gu,Guo Li-Li.Hemodialysis center,Bao Shan Brach of Shanghai No.1 People\' Hospital,Shanghai Jiao Tong University,Shanghai 200940,China |
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| Abstract: | Objective To investigate the effects of L-carnitine supplementation on insulin resistance in nondiabetic hemodialysis patients.Method 41 non-diabetic patients undergoing hemodialysis were divided into two groups:therapy group(n=20) was treated with iv L-carnitine 1.0g twice per week after hemodialysis session for 6 months,21 matched non-diabetic hemodialysis patients no received L-carnitine served as control.Fasting blood glucose,insulin,insulin resistance index(HOMA-IR),and the inflammation marker-C-reacti... |
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| Keywords: | L-carnitine Hemodialysis(HD) Insulin resistance C-reactive protein(CRP) |
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