基质降解酶在前列腺癌诊治中的作用

目的：探讨MMP－9、TIMP－1在前列腺癌组织中的表达与前列腺癌预后的关系。方法：用免疫组化方法测定前列腺癌32例和前列腺增生30例标本的MMP－9、TIMP－1表达,分析肿瘤标志物的表达与前列腺癌分期和分级的关系。结果：MMP－9的实验组和对照组的表达比较统计学上有显性差异,MMP－9表达和前列腺癌分化程度的临床分期有关。结论：MMP－9和TIMP－1的表达测定可作为一项判断前列腺癌生物学行为指标。

Action of Matriz Metallopoteinase in Diagnosis and Therapy of Prostatic Cancer

Objective To study the relation between the clinical outcome stage and the expression of MMP 9 and TIMP 1 in prostate cancer.Methods The tumor makers,MMP 9 and TIMP 1 were detected with immohistochemistry method in 32 prostate carcinoma and 30 benign prostate hyperplasia.The relationship between expression of tumor makers and tumor grade and clinical stage was analyzed.Results Significant difference was found in MMP 9 between prostate carcinoma and benign prostate hyperplasia.It's also found that MMP 9 were correlated with the stage and grade of prostate cancer.Conclusions:It is believed that MMP 9 and TIMP 1 can be used as a prometer for the biologic actions of prostate carcinoma.