| 活化蛋白C抵抗与复发性流产关系的研究 |
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| 引用本文： | 董卫红,魏文宁,林美华. 活化蛋白C抵抗与复发性流产关系的研究[J]. 中华妇产科杂志, 2000, 35(2): 85-86 |
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| 作者姓名： | 董卫红 魏文宁 林美华 |
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| 作者单位： | 同济医科大学附属协和医院妇产科(董卫红!430022武汉，林美华!430022武汉)，同济医科大学附属协和医院血液研究所(魏文宁!430022武汉) |
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| 摘 要： | 目的 探讨活化蛋白Ｃ抵抗（ＡＰＣ－Ｒ）与复发性流产的关系。方法 用以活化部分凝血活酶时间（ＡＰＴＴ）为基础的ＡＰＣ－Ｒ方法。检测４０例已产非孕妇女（对照组），５５例原因不明复发性流产患者（实验组）ＡＰＣ－Ｒ的阳性率。结果 对照组ＡＰＣ－Ｒ阳性率为５％，实验组为２６％，两者比较，差异有极显著性（Ｐ〈０．０１）。仅有两次流产者和有３次以上流产者的ＡＰＣ－Ｒ阳性率分别为２３％和２９％，两者比较，差异无显
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| 关 键 词： | 流产 蛋白质C 抗药性 |
| 修稿时间： | 1999-01-06 |
Study on Relationship ofActivated Protein C Resistance and Recurrent Spontaneous Abortion |
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| DONG Weihong ,WEI Wenning,LIN Meihua. Study on Relationship ofActivated Protein C Resistance and Recurrent Spontaneous Abortion[J]. Chinese Journal of Obstetrics and Gynecology, 2000, 35(2): 85-86 |
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| Authors: | DONG Weihong WEI Wenning LIN Meihua |
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| Affiliation: | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical University, Wuhan 430022, China. |
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| Abstract: | Objective To investigate whether activated protein C resistance (APC R) is associated with recurrent spontaneous abortion. Methods APC R was detected by activated partial thromboplastin time (APTT) in the presence and absence of APC. Subjects included 40 nonpregnant parous women (control group) and 55 patients with recurrent spontaneous abortion. Results There was signficant difference for APC R between controls and the patients ( P <0.01). Among the study group,the prevalence of APC R positive rate had no relation to the numbers of abortion. The positive rate of APC R in patients with late abortion was significantly higher than those with only early abortion (38% and 12% respectively). Conclusion APC R is partly associated with recurrent spontaneous abortion, especially late abortion.It has no relation to the numbers of abortion. |
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| Keywords: | Abortion Protein C Drug resistance |
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