| 参麦注射液对脑出血大鼠神经细胞凋亡相关基因表达影响的实验研究 |
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| 引用本文： | 何泽云,屈波,李晓峰.参麦注射液对脑出血大鼠神经细胞凋亡相关基因表达影响的实验研究[J].中国中药杂志,2004,29(12):1160-1165. |
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| 作者姓名： | 何泽云 屈波 李晓峰 |
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| 作者单位： | 1. 浙江大学,医学院,第一附属医院,浙江,杭州,310003
2. 湖南中医学院,湖南,长沙,410007 |
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| 基金项目： | 国家自然科学基金，湖南省自然科学基金，中国博士后科学基金 |
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| 摘 要： | 目的 :观察参麦注射液对大鼠脑出血后神经细胞凋亡相关基因的影响。方法 :采用Rosenberg法复制大鼠脑出血模型 ,测定脑出血后大鼠海马CA1区神经细胞病理形态结构及其Bcl-2基因、Bax基因表达 ;结果 :参麦注射液减少大鼠脑出血后海马CA1区锥体细胞凋亡数目 ,显著增加Bcl-2基因表达 ,降低Bax基因表达 ,使BaxmR NA/bcl-2 mRNA比率下降。结论 :参麦注射液能调节凋亡基因 ,减少大鼠脑出血后神经细胞的凋亡。
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| 关 键 词： | 参麦注射液 脑出血 神经元凋亡 凋亡相关基因 |
| 文章编号： | 1001-5302(2004)12-1160-06 |
| 收稿时间： | 2004/3/17 0:00:00 |
The experimental study of the effects of Shenmai injection on the neuronal apoptosis related gene expression in rat brain after intracerebral hemorrhage |
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| HE Ze yun ;QU Bo ;LI Xiao feng.The experimental study of the effects of Shenmai injection on the neuronal apoptosis related gene expression in rat brain after intracerebral hemorrhage[J].China Journal of Chinese Materia Medica,2004,29(12):1160-1165. |
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| Authors: | HE Ze yun ;QU Bo ;LI Xiao feng |
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| Abstract: | Objective: To observe the effects of Shenmai(SM) injection on the neuronal apoptosis related gene expression in rat brain after intracerebral hemorrhage Method: With Rosenberg models of rat intracerebral hemorrhage, we studied the pathologic changes of neuronal structure in hippocampal CA1 areas and gene expression of Bax and Bcl-2 Result: SM injection had effects on inhibiting the pyramidal cells apoptosis in the hippocampal CA1 areas, increasing the expression of Bcl-2 gene, and reducing the expression of Bax gene resulting deceased the ratio of Bax mRNA /Bcl-2 mRNA Conclusion: SM injection can regulate the apoptosis gene, and inhibit the apoptosis in rat brain after intracerebral hemorrhage. |
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| Keywords: | Shenmai Injection intracerebral hemorrhage neuronal apoptosis apoptosis related gene |
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