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| 失血性休克对大鼠肠道细菌易位和血浆内毒素水平的影响及其意义 | |
| 引用本文： | 陈学云,颜荣林,王来根,王岚,顾军,王绍明. 失血性休克对大鼠肠道细菌易位和血浆内毒素水平的影响及其意义[J]. 中华急诊医学杂志, 2002, 11(2): 92-94 |
| 作者姓名： | 陈学云 颜荣林 王来根 王岚 顾军 王绍明 |
| 作者单位： | 1. 200003,上海,第二军医大学长征医院普外科 2. 200003,上海,第二军医大学长征医院病理科 3. 200003,上海,第二军医大学长征医院实验科 4. 200003,上海,上海市临床检验中心 |
| 基金项目： | 全军协作攻关资助课题 ( 1 0 2 0 0 6 1) |
| 摘 要： | 目的 探讨失血性休克对肠道细菌易位和血浆内毒素水平的影响。方法 采用甲基－^3胸腺嘧啶核苷（[^3H]-TdR）标记致病人肠杆菌，大失血性休克前注入大鼠的胃肠道，然后于失血性休克的不同阶段，通过检测^3H的放射活性和应用放射自显影的方法进行示踪，同时检测血浆内毒素的含量。结果 失血性休克早期即可发生肠源性内毒素血症；当休克发展到一定严重程度时，肠道细菌可进入血液循环，并侵及多个脏器。结论 失血性休克可致肠源性内毒素血症和肠道细菌易位性感染。 |
| 关 键 词： | 失血性休克 内毒素 易位感染 肠道细菌 动物实验 |
| 修稿时间： | 2001-09-24 |
The effect of hemorrhagic shock on intestinal bacterial translocation and plasma endotoxin level in rats |
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| CHEN Xueyun,YAN Ronglin,WANG Laigen,et al.. The effect of hemorrhagic shock on intestinal bacterial translocation and plasma endotoxin level in rats[J]. Chinese Journal of Emergency Medicine, 2002, 11(2): 92-94 | |
| Authors: | CHEN Xueyun YAN Ronglin WANG Laigen et al. |
| Affiliation: | CHEN Xueyun,YAN Ronglin,WANG Laigen,et al.Department of General Surgery,Changzheng Hospital,Second Military Medical University of PLA.,Shanghai 200003,China |
| Abstract: | Objective To investigate the effect of hemorrhagic shock on intestinal bacterial translocation and plasma endotoxin level in rats.Methods Pathogenic Escherichia Coli labelled with methylated 3 H thymidine was infused into experimental rat ' s intestine before hemorrhagic shock.At different time of shock, 3H radioactivity was assayed,tracer was tested with radioautography,plasma endotoxin level was examined.Results In the early phase of hemorragic shock,endotoxemia originated from the gut may occur,when shock progresses to a serious extent,intestinal bacteria may migrate to the systemic blood circulation and many organs.Conclusion Hemorrhagic shock can induce endotoxemia and infection originating from the gut. |
| Keywords: | Shock Hemorrhagic Endotoxin Bacterial translocation |
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