Antibody-Dependent Lymphocyte-Mediated Cytotoxicity in an Allogeneic Human System |
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| Authors: | E. DICKMEISS L. S. NIELSEN |
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| Affiliation: | Medical Department P, Division of Nephrology, and Tissue Typing Laboratory and Blood Grouping Department, State University Hospital, Copenhagen, Denmark |
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| Abstract: | ![]()
The in vitro reactivity of human alloimmune sera against human lymphocytes in a complement-dependent system is compared with the reactivity in a system based on the principle of antibody-dependent lymphocyte-mediated cytotoxicity (ADLC). The sensitivity by which ADLC detects antibody reactivity is a 100- to a 1000-fold greater than the sensitivity of the complement-dependent system. With a given serum, ADLC discloses reactivity against many more different lymphocytes than the complement-dependent system. This substantially broader reactivity in ADLC is presumably caused by cross-reactions in the HL-A system. |
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