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Immune response in Balb/c mice induced by recombinant spike protein of severe acute respiratory syndrome coronavirus |
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| Authors: | Qin Li Wu Shao-ting Wang Xi-ming Yuan Shi-shan Huang Da-na Lei Ming-jun Pan Hui-rong Lin Qi-ping Gao Shi-tong Zhang Ren-li Qu Shen |
| Affiliation: | 1. Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2. Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China 3. Veterinarian College, South China University of Agriculture, Guangzhou 510000, China |
| Abstract: | Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly aggressive pathogen that caused SARS in 2003 and 2004.~(1-4) Spike protein (S) on the surface of virus particles mediates the attachment of the virus to cell surface receptors and induces the fusion of viral and cellular membranes. According to the epitope analysis and structure of S protein, we used two fragments of S protein S1 (108-488aa) and S2 (723-938aa) expressed in Escherichia coli and immunized Balb/c mice to investigate the immune response to the recombinant proteins in mice.~5 |
| Keywords: | severe acute respiratory syndrome coronavirus spike protein IgG isotype T lymphocyte subset cytokine |
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