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Effects of immunosuppressors and cytostatics on the extracellular matrix production in experimental nephropathy
Authors:L G Krivoshchapov  E M Pal'tseva
Institution:(1) Faculty of Pedagogical Staff Training, I. M. Setchenov Moscow Medical Academy, Moscow, USSR
Abstract:Methylprednisolone increased the content of laminine, cyclosporin increased the content of fibronectin, and cyclophosphamide suppressed the extracellular matrix production in experimental nephrotoxic nephritis and puromycin aminonucleoside nephrosis. Therapy should be chosen with due consideration of the extracellular matrix structure in different morphological variants of chronic glomerulonephritis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 584–587, November, 1998
Keywords:extracellular matrix                      prednisolone                      cyclophosphamide                      cyclosporin A
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