|
|||||
|
|
| 血红素氧化酶1基因在慢性肺心病大鼠支气管中的定位表达 | |
| 引用本文： | 黄晓颖,王良兴,陈少贤,徐正祄,龚永生. 血红素氧化酶1基因在慢性肺心病大鼠支气管中的定位表达[J]. 温州医学院学报, 2003, 33(1): 4-5 |
| 作者姓名： | 黄晓颖 王良兴 陈少贤 徐正祄 龚永生 |
| 作者单位： | 1. 温州医学院第一附属医院,呼吸内科,浙江,温州,325027 2. 温州医学院,肺心病研究室,浙江,温州,325027 |
| 基金项目： | 浙江省自然科学基金资助项目 (30 14 84) |
| 摘 要： | 目的：研究血红素氧化酶—1(HO—1)基因在慢性肺心病大鼠支气管中的表达及分布情况。方法：采用免疫组化、组织原位杂交等技术，对慢性低氧高二氧化碳诱发的肺心病大鼠支气管中的HO-1表达进行定位研究。结果：HO—1及其mRNA在慢性肺心病大鼠各级支气管上皮细胞和平滑肌细胞中广泛表达。结论：对于慢性低氧高二氧化碳诱发的肺心病，HO—1在支气管的表达被诱导。 |
| 关 键 词： | 支气管 血红素氧化酶 低氧 高碳酸血 原位杂交 |
| 文章编号： | 1000-2138(2003)01-004-02 |
| 修稿时间： | 2001-11-09 |
Expression of heme oxygenase-1 in the bronchis of rats with chronic col pulmonale |
|
| HUANG Xiao ying ,WANG Liang xing,CHEN Shao xian,et al.. Expression of heme oxygenase-1 in the bronchis of rats with chronic col pulmonale[J]. Journal of Wenzhou Medical College, 2003, 33(1): 4-5 | |
| Authors: | HUANG Xiao ying WANG Liang xing CHEN Shao xian et al. |
| Affiliation: | HUANG Xiao ying *,WANG Liang xing,CHEN Shao xian,et al.* Iinstitute of Cor Pulmonale,Wenzhou Medical College,Wenzhou 325027 |
| Abstract: | Objective:To study the expression of heme oxygenase 1(HO 1) in the bronchis of rats with chronic col pulmonale.Methods:By the technique of immunohistochemistry and in situ hybridization , the expression of HO 1 was observed in the bronchis of rats with chronic col pulmonale induced by chronic hypoxia and hypercapnia.Results:The HO 1 expression presented widely in the epithelia and the smooth muscle cells of bronchis.Conclusion:Expression of HO 1 in bronchis was induced in chronic col pulmonale induced by chronic hypoxia and hypercapnia. |
| Keywords: | bronchi heme oxygenase anoxia hypercapnia in situ hybridization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |