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| 砷剂治疗非急性早幼粒细胞白血病恶性血液病的临床观察 | |
| 引用本文： | 王文生,邱志祥,李渊,岑溪南,任汉云. 砷剂治疗非急性早幼粒细胞白血病恶性血液病的临床观察[J]. 中国肿瘤临床与康复, 2005, 12(6): 517-520 |
| 作者姓名： | 王文生 邱志祥 李渊 岑溪南 任汉云 |
| 作者单位： | 北京大学第一医院血液内科,北京,100034 |
| 摘 要： | 目的观察亚砷酸治疗非急性早幼粒细胞白血病(APL)恶性血液病的疗效和毒副反应.方法分析亚砷酸在治疗5例非霍奇金淋巴瘤(NHL)、1例多发性骨髓瘤(MM)、3例骨髓异常增生综合征(MDS)中的疗效和毒副反应.结果 NHL患者CR 2例,PR 1例;MM患者无效1例; MDS患者1例达到细胞遗传学缓解.毒副反应有骨髓抑制、发热、皮疹、胸腔积液、肾功能损害等.结论可以看到亚砷酸治疗非APL恶性血液病有效的趋势. |
| 关 键 词： | 砷剂 白血病/化学疗法 |
| 文章编号： | 1005-8664(2005)06-0517-04 |
| 修稿时间： | 2005-09-15 |
Clinical analysis of the effect of arsenic trioxide on treating non-APL hematologic malignancy |
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| WANG Wen-sheng,QIU Zhi-xiang,LI Yuan,et al. Clinical analysis of the effect of arsenic trioxide on treating non-APL hematologic malignancy[J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2005, 12(6): 517-520 | |
| Authors: | WANG Wen-sheng QIU Zhi-xiang LI Yuan et al |
| Abstract: | Objective To investigate the clinical efficacy and toxicity of arsenic trioxide on treating non-APL hematologic malignancy.Methods Analyzed the treatment effects and side effects in 5 cases of NHL,1 case of MM and 3 cases of MDS.Results 2 cases achieved CR and 1 PR in 5 NHL,respectively,1 NR in MM,1 case achieved cytogenetic remission in 3 MDS.The side effects of arsenic trioxide were arrest of bone marrow,fever,skin rash,hydrothorax,impairment of renal function.Conclusion Arsenic trioxide tended to be effective on treating non-APL hematologic malignancy. |
| Keywords: | Arsenic trioxide Leukemia/chemotherapy |
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