| 苏木对同种异位心脏移植大鼠心肌穿孔素mRNA表达的影响 |
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| 引用本文： | 周亚滨,姚凤祯,韩佳瑞,杨焱,张春芳,石月平. 苏木对同种异位心脏移植大鼠心肌穿孔素mRNA表达的影响[J]. 中国中西医结合杂志, 2003, 23(5): 370-372 |
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| 作者姓名： | 周亚滨 姚凤祯 韩佳瑞 杨焱 张春芳 石月平 |
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| 作者单位： | 黑龙江中医药大学附属第一医院,哈尔滨,150040 |
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| 基金项目： | 黑龙江省教育厅科研课题 |
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| 摘 要： | 目的：观察苏木(Sappan Wood)对同种异位心脏移植大鼠心肌穿孔素(perforin，PFP)mRNA表达的影响。方法：以Wistar大鼠为供体，以SD大鼠为受体，建立腹腔异位心脏移植模型，以RT—PCR法检测苏木对穿孔素mRNA表达的影响。结果：苏木可明显降低穿孔素mRNA的表达，并能明显减轻病理形态学及心肌细胞超微结构的损伤。结论：苏木有明显的抗免疫排斥作用，可能是通过降低穿孔素mRNA的表达而发挥免疫抑制的作用。
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| 关 键 词： | 苏木 同种异位心脏移植 心肌穿孔素 mRNA 表达 |
| 修稿时间： | 2002-03-13 |
Effect of Sappan Wood on Perforin mRNA Expression in Myocardium of Rats after Allogeneic Cardiac Transplantation |
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| ZHOU Ya bin,YAO Feng zhen,HAN Jia rui. Effect of Sappan Wood on Perforin mRNA Expression in Myocardium of Rats after Allogeneic Cardiac Transplantation[J]. Chinese journal of integrated traditional and Western medicine, 2003, 23(5): 370-372 |
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| Authors: | ZHOU Ya bin YAO Feng zhen HAN Jia rui |
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| Abstract: | OBJECTIVE: To observe the effect of Sappan wood (SW) on the expression of perforin mRNA in myocardium of rats after allogeneic cardiac transplantation. METHODS: The animal model of allogeneic (abdominal) cardiac transplantation was established by taking Wistar rat as provider and SD rat as receptor, perforin mRNA expression in the model's myocardium was detected by RT-PCR. RESULTS: SW could obviously reduce the perforin mRNA expression, it also could alleviate the pathological morphology and ultrastructural damage of myocardial cells. CONCLUSION: SW has obvious effect in antagonizing immune rejection after transplantation, the mechanism of its immunosuppression could be through lowering the perforin mRNA expression. |
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| Keywords: | Sappan Wood allogeneic cardiac transplantation perforin |
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