| 美沙拉嗪颗粒联合双歧三联活菌胶囊对溃疡性结肠炎患者血清SOD、MDA的影响 |
| |
| 引用本文： | 安丽婷,霍丽娟,师永盛.美沙拉嗪颗粒联合双歧三联活菌胶囊对溃疡性结肠炎患者血清SOD、MDA的影响[J].山西医科大学学报,2011,42(5):416-419. |
| |
| 作者姓名： | 安丽婷 霍丽娟 师永盛 |
| |
| 作者单位： | 山西医科大学第一临床医学院消化科,太原,030001 |
| |
| 摘 要： | 目的探讨美沙拉嗪颗粒(艾迪莎)与双歧三联活菌胶囊(培菲康)联合治疗对溃疡性结肠炎(UC)患者血清中丙二醛(MDA)浓度和超氧化物歧化酶(SOD)活力的影响。方法 38例UC患者随机分为两组:对照组和治疗组,每组各19例。对照组给予美沙拉嗪颗粒(1.0 g/次,4次/d),治疗组在此基础上加用双歧三联活菌胶囊(420 mg/次,3次/d),疗程均为2个月。比较治疗前后UC患者血清中MDA浓度和SOD活力,同时对治疗前后两组患者临床疗效进行评价。结果治疗组和对照组MDA浓度均较治疗前降低(P<0.05),SOD活力较治疗前上升(P<0.05)。两组治疗前后差值比较,差异也有统计学意义(P<0.05)。治疗组总有效率高于对照组(P<0.05)。结论美沙拉嗪颗粒联合双歧三联活菌胶囊治疗UC较单独使用美沙拉嗪颗粒可更明显地降低MDA的水平,升高SOD活力。
|
| 关 键 词： | 溃疡性结肠炎 氧自由基 美沙拉嗪 培菲康 |
Effect of combination of mesalazine and bifico on serum SOD, MDA in patients with ulcerative colitis |
| |
| AN Li-ting,HUO Li-juan,SHI Yong-sheng.Effect of combination of mesalazine and bifico on serum SOD, MDA in patients with ulcerative colitis[J].Journal of Shanxi Medical University,2011,42(5):416-419. |
| |
| Authors: | AN Li-ting HUO Li-juan SHI Yong-sheng |
| |
| Institution: | AN Li-ting,HUO Li-juan,SHI Yong-sheng (Dept of Gastroenterology,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China) |
| |
| Abstract: | Objective To evaluate the effect of combination of mesalazine and bifico on serum levels of malondialdehyde(MDA)and superoxide dismutase(SOD)in patients with ulcerative colitis(UC). Methods Thirty-eight patients with UC were randomly divided into two groups:control group(n=19) and treatment group(n=19).Patients in control group were given mesalazine,while patients in treatment group were additionally given bifico 420 mg,tid for 2 months as a course.Serum MDA level and SOD activity were detected in UC patien... |
| |
| Keywords: | ulcerative colitis oxygen free radicals mesalazine bifico |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
