骨巨细胞瘤发生与p16和Rb蛋白表达的关系

目的 探讨ｐ１６和Ｒｂ蛋白表达与骨巨细胞瘤发生的关系。方法 采用免疫组织化学链霉菌抗生物素－过氧化物酶法（ＳＰ）检测４２例骨巨细胞瘤的ｐ１６与Ｒｂ蛋白表达。研究不同病理分级的骨巨细胞瘤ｐ１６蛋白表达及Ｒｂ蛋白表达之间的关系。结果 骨巨细胞瘤ｐ１６蛋白表达缺失率为６６．７％,ｐ１６蛋白表达随骨白细胞瘤恶性程度的上升而减低。Ｒｂ蛋白表达缺失率为４２．９％。６６．７％的病例存在ｐ１６与Ｒｂ蛋白表达的倒置

The relationship between p16, Rb protein expression and the genesis of giant cell tumor of bone

Objective Discuss the relationship between the expression of p16, Rb protein and the carcinogenesis of giant cell tumor of bone. Methods Immunohistochemical method was used to assess p16 and Rb protein expression in 42 cases of giant cell tumor of bone. Results The absent expression rate of p16 protein was 66.7%.The expression of p16 protein decreased as the malignant extent of giant cell tumor of bone increased. The absent expression rate of Rb protein was 42.9%. All 66.7% cases had reverse relationship between p16 and Rb protein expression. Conclusion The decrease of p16 protein expression was associated with the carcinogenesis of giant cell tumor of bone. The inactivation of p16 Rb route may play an important role in the carcinogenesis of giant cell tumor of bone.