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重视抗血管内皮生长因子疗法在渗出型老年性黄斑变性治疗应用中的问题
引用本文:王雨生,侯慧媛. 重视抗血管内皮生长因子疗法在渗出型老年性黄斑变性治疗应用中的问题[J]. 中华眼底病杂志, 2010, 26(1): 6-8. DOI: 10.3760/cma.j.issn.1005-1015.2010.01.02
作者姓名:王雨生  侯慧媛
作者单位:第四军医大学西京医院眼科,全军眼科研究所,西安,710032
基金项目:国家自然科学基金,教育部留学回国人员科研启动基金 
摘    要:
抗血管内皮生长因子疗法的应用是渗出型老年性黄斑变性治疗中的重大突破,但作为一种新兴疗法,其疗效持久性、药物副作用、药物选择等方面存在的问题也正逐步显现。充分认识该疗法的局限性以及应用过程中可能发生的副作用,加强临床监测,提倡个体化治疗,以提高其疗效和安全性是值得关注和重视的问题。

关 键 词:黄斑变性/药物疗法  脉络膜新生血管化/药物疗法  抗体, 单克隆/治疗应用  抗体, 单克隆/副作用  血管内皮生长因子类
收稿时间:2009-10-19

Concerns about anti-vascular endothelial growth factor therapy for exudative age-related macular degeneration treatment
WANG Yu-sheng,HOU Hui-yuan. Concerns about anti-vascular endothelial growth factor therapy for exudative age-related macular degeneration treatment[J]. Chinese Journal of Ocular Fundus Diseases, 2010, 26(1): 6-8. DOI: 10.3760/cma.j.issn.1005-1015.2010.01.02
Authors:WANG Yu-sheng  HOU Hui-yuan
Abstract:
The introduction of anti-vascular endothelial growth factor (VEGF) therapy represents a landmark in the management of wet age-related macular degeneration (AMD). However, as a new therapy, several problems such as durability of the therapeutic effects, medication side effects, and medication selection have emerged. We should make appoint of improving the therapeutic effect and safety by realizing the limitation of the therapy, monitoring the clinical potential adverse reactions of anti-VEGF agents, and recommending individualized treatment.
Keywords:Macular Degeneration/drug therapy  Choroidal neovascularization/drug therapy  Antibodies, monoclonal/therapeutic use  Antibodies, monoclonal/adverse effects  Vascular endothelial growth factors
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