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Basement membrane proteins in synovial membrane: Distribution in rheumatoid arthritis and synthesis by fibroblast-like cells
Authors:M. Schneider M.D.  B. Voss  J. Rauterberg  M. Menke  Th. Pauly  R. K. Miehlke  J. Friemann  U. Gerlach
Affiliation:(1) Medical Clinic and Policlinic B, University of Münster, Germany;(2) Professional Associations' Research Institute for Occupational Medicine, Bochum;(3) Institute for Arteriosclerosis Research, Münster;(4) Rhine Rheumatology Center Meerbusch, Germany;(5) Northwest German Center of Rheumatology Sendenhorst, Germany;(6) Department of Environmental Pathology of the Institute for Environmental Hygiene at the University of Düsseldorf, Germany;(7) Center for Rheumatology, Medical Clinic and Policlinic B, Westfalian Wilhelms-University, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany
Abstract:
Summary Rheumatoid arthritis is a complex disease of unknown origin. In consequence of some immunological reactions, proliferative invading synovial tissue leads to destruction of normal joint architecture. The aim of this study was to investigate qualitative changes in extracellular matrix distribution of proliferating rheumatoid synovium and their cellular origin. Synovial tissues from 57 clinically indicated arthrotomies were investigated with immunofluorescence, using specific antibodies against extracellular matrix proteins in tissue slides and cultured cells, which were also studied for collagen biosynthesis. Results indicated that synovial fibroblast-like cells synthesize and secrete basement membrane proteins laminin and collagen type IV as e.g. endothelial cells or organogenic fibroblasts. Laminin and collagen type IV were specifically demonstrated pericellularly in the hyperplastic lining layer of active rheumatoid synovitis. These findings are discussed with respect to the possible implication of altered cell-matrix interactions in rheumatoid synovial proliferation.
Keywords:Rheumatoid Arthritis  Synovium  Extracellular Matrix  Basement Membrane Proteins  Immunohistochemistry
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