Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis speciosa |
| |
| Authors: | Nakao Yoichi Yoshida Wesley Y Takada Yuuki Kimura Junji Yang Liu Mooberry Susan L Scheuer Paul J |
| |
| Affiliation: | Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822-2275, USA. ayocha@mail.ecc.u-tokyo.ac.jp |
| |
| Abstract: | ![]()
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
