| 基于磁共振温度图的高强度聚焦超声治疗热剂量研究 |
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| 引用本文： | 刘莉莉,李发琪,龚晓波,刘映江,胡晓. 基于磁共振温度图的高强度聚焦超声治疗热剂量研究[J]. 生物医学工程学杂志, 2010, 0(2) |
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| 作者姓名： | 刘莉莉 李发琪 龚晓波 刘映江 胡晓 |
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| 作者单位： | 重庆医科大学生物医学工程系重庆市超声医学工程重点实验室; |
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| 基金项目： | 国家十一五科技支撑计划资助项目(2006BAI03A02); 国家自然科学基金重点项目资助(30830040); 重庆市科委攻关项目资助(渝科发计字[2007]11号CSTC,2007AA5020) |
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| 摘 要： | 本实验研究基于磁共振T-Map的HIFU损伤组织的热剂量与实际凝固性坏死的关系。运用磁共振导航高强度聚焦超声治疗系统,使用1 MHz、焦距为150 mm、直径150 mm的聚焦超声换能器,定点辐照深度为20 mm的新鲜离体牛肝脏,辐照过程中用磁共振的测温序列采集各体素随时间变化的温度值并计算各体素的Eq43值,比较计算结果与发生凝固性坏死的Eq43参考阈值,判断该体素是否发生坏死。最后比较通过等效热剂量积分法得到的凝固性坏死面积和组织实际发生坏死的情况。结果表明基于磁共振T-Map的等效热剂量积分法得到的凝固性坏死的面积值能很好的反应实际发生凝固性坏死的情况,为HIFU治疗提供了一种新的判断凝固性坏死发生的方法,这种方法可以实时地反馈控制超声辐照剂量,提高了治疗的安全性。
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| 关 键 词： | 磁共振 温度图 高强度聚焦超声 热剂量 |
Research on Thermal Dose for High Intensity Focused Ultrasound Treatment Based on the Temperature-map of Magnetic Resonance Imaging |
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| Liu Lili Li Faqi Gong Xiaobo Liu Yingjiang Hu Xiao. Research on Thermal Dose for High Intensity Focused Ultrasound Treatment Based on the Temperature-map of Magnetic Resonance Imaging[J]. Journal of biomedical engineering, 2010, 0(2) |
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| Authors: | Liu Lili Li Faqi Gong Xiaobo Liu Yingjiang Hu Xiao |
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| Affiliation: | Liu Lili Li Faqi Gong Xiaobo Liu Yingjiang Hu Xiao(Department of Biomedical Engineering,Key Laboratory of Ultrasonic Medicine Engineering,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Based on the T-map of MRI,this research sought to address the relationship between the simulated threshold thermal dose of coagulation and actual the coagulation on histological slides.The MR imaging guided HIFU system was used,the parameters of therapeutic transducer were: frequency-1MHz,diameter-150mm,and focal length-150mm.In fresh beef liver tissue in vitro,sonications were delivered at a fixed depth of 20mm and at varying powers.The temperature-sensitive MR images obtained during the sonications were u... |
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| Keywords: | Magnetic resonance imaging(MRI) Temperature-map (T-Map) High intensity focused ultrasound(HIFU) Thermal dose |
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