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Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate |
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| Authors: | Nadia K Magdalinou Hannah L Golden Jennifer M Nicholas Pirada Witoonpanich Catherine J Mummery Huw R Morris |
| Affiliation: | 1. Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK;2. Dementia Research Centre, UCL Institute of Neurology, London, UK;3. Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK;4. Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;5. Department of Clinical Neuroscience, UCL Institute of Neurology, London, UK |
| Abstract: | ABSTRACTVerbal adynamia (impaired language generation, as during conversation) has not been assessed systematically in parkinsonian disorders. We addressed this in patients with Parkinson’s dementia, progressive supranuclear palsy and corticobasal degeneration. All disease groups showed impaired verbal fluency and sentence generation versus healthy age-matched controls, after adjusting for general linguistic and executive factors. Dopaminergic stimulation in the Parkinson’s group selectively improved verbal generation versus other cognitive functions. Voxel-based morphometry identified left inferior frontal and posterior superior temporal cortical correlates of verbal generation performance. Verbal adynamia warrants further evaluation as an index of language network dysfunction and dopaminergic state in parkinsonian disorders. |
| Keywords: | Parkinson’s disease Lewy body disease progressive supranuclear palsy corticobasal degeneration dynamic aphasia |