| 血管母细胞瘤40例临床病理分析 |
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| 引用本文： | 周春辉,郝卓芳,廖德贵,陆光明,黄世章.血管母细胞瘤40例临床病理分析[J].临床与实验病理学杂志,2010,26(1). |
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| 作者姓名： | 周春辉 郝卓芳 廖德贵 陆光明 黄世章 |
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| 作者单位： | 广州医学院第二附属医院病理科,广州,510260 |
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| 摘 要： | 目的探讨血管母细胞瘤临床病理学特征、影像学特点、免疫表型、诊断及鉴别诊断。方法应用HE染色和免疫组化标记等方法对40例血管母细胞瘤进行病理学特征观察,同时分析其CT和MRI影像学特点。结果40例血管母细胞瘤临床表现主要为头晕、头痛、呕吐、视乳头水肿、共济失调等。CT和MRI检查示颅内界限尚清的囊实性病变,内有壁结节,增强扫描后囊性部分无强化,附壁结节明显强化。组织学检查肿瘤主要由两种成分构成:即不同成熟阶段的毛细血管和毛细血管网之间丰富的间质细胞。免疫组化肿瘤组织中的血管内皮细胞均表达CD34和FⅧRAg,间质细胞大多表达S-100,少数表达NSE,血管内皮细胞和间质细胞均表达vimentin,而一般不表达GFAP、EMA和p53,Ki-67表达较低或不表达。结论血管母细胞瘤主要由不同成熟阶段的毛细血管和来源未定的肿瘤性间质细胞构成。其影像学表现具有一定的特异性。血管母细胞瘤须注意与毛细胞型星形细胞瘤、血管瘤型脑膜瘤、转移性肾癌等鉴别。
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| 关 键 词： | 血管母细胞瘤/病理学 免疫组织化学 影像学 |
Hemangioblastoma: clinicopathologic analyses of 40 cases |
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| ZHOU Chun-hui,HAO Zhuo-fang,LIAO De-gui,LU Guang-ming,HUANG Shi-zhang.Hemangioblastoma: clinicopathologic analyses of 40 cases[J].Chinese Journal of Clinical and Experimental Pathology,2010,26(1). |
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| Authors: | ZHOU Chun-hui HAO Zhuo-fang LIAO De-gui LU Guang-ming HUANG Shi-zhang |
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| Institution: | Department of Pathology/a>;Second Affiliated Hospital of Guangzhou Medical College/a>;Guangzhou 510260/a>;China |
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| Abstract: | Purpose To analyze the clinicopathologic features,immunophenotypes,image features and diagnosis of hemangioblastoma.Methods The clinical and pathological features were studied with HE and immunohistochemical staining in 40 cases of hemangioblastoma.The image features were studied with CT and MRI.Results The clinical symptoms of these cases were dizziness,headache,vomitting,optic disc edema and ataxia.The CT and MRI showed a sharply demarcated tumor with cystic areas and a solid mural nodule.After enhancemen... |
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| Keywords: | hemangioblastoma/pathology immunohistochemistry image features |
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