超急性期轻度脑外伤患者静息态功能性磁共振成像研究

目的利用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-f MRI)低频振幅(amplitude of low-frequency fluctuation,ALFF)探讨超急性期(24 h)轻度脑外伤(mild traumatic brain injury,m TBI)患者脑功能的异常变化。材料与方法选取符合纳入标准的52例m TBI患者(m TBI组)及与之相匹配的21名健康者(对照组)行rs-f MRI扫描,并应用静息态脑功能数据辅助处理(data processing assistant for resting state f MRI,DPARSF)软件进行预处理,对2组的ALFF进行对比分析。结果与健康对照组相比,ALFF显著减低的区域有小脑后叶、右枕叶中回及中央后回;ALFF显著增高的区域有双侧额叶、内侧前额叶、双侧尾状核及岛叶。结论在常规磁共振成像无异常发现的情况下,ALFF技术可以更好地发现m TBI患者超急性期静息态脑功能的异常。

Study on resting-state functional magnetic resonance imagingin hyperacute phase of mild traumatic brain injury

Objective: To investigate the abnormal changes of brain function in the hyperacute period (<24 h) patients with mild traumatic brain injury (mTBI) by using the amplitude of low-frequency fluctuation (ALFF) in resting state functional magnetic resonance imaging (rs-fMRI). Materials and Methods: 52 mTBI patients (mTBI group) and matched 21 healthy subjects (control group) underwent rs-fMRI examination. The DPARSF software was used to preprocess the fMRI data, the ALFF was compared between the mTBI and control group. Results: Compared with the healthy control group, the mTBI group showed significantly decreasing ALFF values in cerebellum posterior lobe, right middle occipital gyrus and postcentral gyrus. And the ALFF values increased in bilateral frontal lobe, bilateral caudate,medial frontal gyri and insula. Conclusions: In the case of normal routine MRI findings, ALFF technology showed to be more sentitive in detecting rs-fMRI abnormalities in patients with hyperacute mTBI.