静息态功能磁共振在阿尔茨海默病早期诊断的研究进展

阿尔茨海默病(Alzheimerˊs disease,AD)是最常见的一种老年性痴呆,临床主要表现为进行性记忆力减退、认知障碍。AD发病隐匿,病程缓慢,发现时已经不可逆转,因此对其早期识别与干预至关紧要,血氧水平依赖(blood oxygen level dependent,BOLD)的静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-f MRI)已逐渐发展为探索AD脑功能改变的新途径之一,已有大量研究表明AD患者默认网络(default mode network,DMN)相关脑区局部功能活动及连接异常,作者就静息态BOLD-f MRI在AD脑功能研究中的应用予以综述。

The research progress of early diagnose of Alzheimer's disease by resting state functional magnetic resonance

Alzheimer's disease is the most common type of senile dementia. Clinically, AD is mainly characterized by progressive memory loss and cognitive impairment.It has been irreversible when realizing, so early identification and preventing is crucial. In recent years, resting-functional MRI (rs-fMRI) based on blood oxygen level dependent (BOLD) has become a new means to explore the AD brain functional abnormity, a large number of studies have shown that local functional activities and connection anomalies in the associated brain regions of default mode network (DMN) in the AD, this paper reviews the application in the AD brain's function in terms of resting state BOLD-fMRI.