| 重组人促红细胞生成素对急性高眼压兔视网膜bcl-2蛋白表达的影响 |
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| 引用本文： | 王建明,宋艳萍,孙乃学,惠娜,赵世平,胡凯. 重组人促红细胞生成素对急性高眼压兔视网膜bcl-2蛋白表达的影响[J]. 南方医科大学学报, 2010, 30(3): 552 |
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| 作者姓名： | 王建明 宋艳萍 孙乃学 惠娜 赵世平 胡凯 |
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| 作者单位： | 西安交通大学医学院第二附属医院眼科,陕西,西安,710004;西安市中心医院血液科,陕西,西安,710003 |
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| 基金项目： | 陕西省科技攻关资助项目(2008K14-07);;西安市社发医药卫生研究资助项目(SF08004-2) |
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| 摘 要： | 目的探讨全身应用重组人促红细胞生成素(rhEPO)对急性高眼压兔眼视网膜bcl-2蛋白表达的影响及意义。方法在设立正常对照、急性高眼压模型对照的情况下,日本大耳白兔皮下注射rhEPO,分别于造模后第1、3、7、14天免疫组化法观察视网膜bcl-2蛋白表达。结果正常视网膜组织可见bcl-2蛋白表达,染色阳性细胞数为每高倍视野(10.5±1.2)个。模型组和EPO组兔眼视网膜bcl-2蛋白表达阳性细胞数均较正常对照组减少(P<0.05,P<0.01)。EPO组第7天、14天视网膜bcl-2蛋白表达阳性细胞数较模型组增加(P<0.05,P<0.01)。结论rhEPO可以上调视网膜bcl-2蛋白表达,这可能是rhEPO保护急性高眼压引起的兔眼视网膜神经功能损害的机制之一。
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| 关 键 词： | 促红细胞生成素 bcl-2蛋白 视网膜 神经保护 |
Effect of recombinant human erythropoietin on bcl-2 protein expression in the retina in a rabbit model of acute high intraocular pressure |
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| WANG Jian-ming,SONG Yan-ping,SUN Nai-xue,HUI Na,ZHAO Shi-ping,HU Kai. Effect of recombinant human erythropoietin on bcl-2 protein expression in the retina in a rabbit model of acute high intraocular pressure[J]. Journal of Southern Medical University, 2010, 30(3): 552 |
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| Authors: | WANG Jian-ming SONG Yan-ping SUN Nai-xue HUI Na ZHAO Shi-ping HU Kai |
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| Affiliation: | WANG Jian-ming1,SONG Yan-ping2,SUN Nai-xue1,HUI Na1,ZHAO Shi-ping1,HU Kai2 1Department of Ophthalmology,Second Affiliated Hospital,Xi'an Jiaotong University College of Medicine,Xi'an 710004,China,2Department of Hematology,Xi'an Central Hospital,Xi'an 710003 |
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| Abstract: | Objective To investigate the effect of recombinant human erythropoietin (rhEPO) on the expression of bcl-2 protein in the retina of rabbits with acute high intraocular pressure and explore the mechanism underlying the protective effect of rhEPO on the retina against ischemia-reperfusion injury. Methods rhEPO was injected subcutaneously in the ear of a rabbit model of acute high intraocular pressure induced by physiological saline perfusion into the anterior chamber. Bcl-2 protein expression in the retina of... |
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| Keywords: | erythropoietin bcl-2 protein retina neuroprotection |
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