A New Platelet Antigen System, Yuka/Yukb |
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| Authors: | Yoichi Shibata Toru Miyaji Yoichi Ichikawa and Isao Matsuda |
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| Affiliation: | Department of Immunohematology, Toranomon Hospital, and Okinaka Memorial Institute for Medical Research, Tokyo;Departments of Pediatrics, Saitama Medical School, Saitama, Japan;Departments of Bacteriology, Saitama Medical School, Saitama, Japan;Department of Obstetrics and Gynecology, Morioka Red Cross Hospital, Iwate, Japan |
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| Abstract: | We report a new platelet antigen (Yukb) involved in a case of neonatal alloimmune thrombocytopenia (NAITP). This antigen is considered to be a product of an allele of the Yuk gene, another allele of which codes for Yuka which was involved in 2 cases of NAITP. The Yuka and Yukb antigens are not expressed on thrombasthenic platelets which suggests that these antigens are present on platelet glycoprotein IIb and/or IIIa. The gene frequencies for Yuka and Yukb in the Japanese population were estimated to be 0.0083 and 0.9917, respectively. |
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