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Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control
Authors:Carin K. Ingemarsdotter  Laura A. Tookman  Ashley Browne  Katrina Pirlo  Rosalind Cutts  Claude Chelela  Karisma F. Khurrum  Elaine Y.L. Leung  Suzanne Dowson  Lee Webber  Iftekhar Khan  Darren Ennis  Nelofer Syed  Tim R. Crook  James D. Brenton  Michelle Lockley  Iain A. McNeish
Affiliation:1.Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK; 2.Institute of Cancer Sciences, University of Glasgow, Glasgow, UK; 3.Cancer Research UK and UCL Clinical Trials Centre, London, UK; 4.Division of Brain Sciences, Faculty of Medicine, Imperial College, London, UK; 5.Dundee Cancer Centre, University of Dundee, Ninewells Hospital, Dundee, UK; 6.Cancer Research UK Cambridge Institute, Cambridge, UK
Abstract:
Keywords:Ovarian cancer   Paclitaxel resistance   Adenovirus   Coxsackie adenovirus receptor   Cell cycle control
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