恶性血液病患者医院感染临床分析

目的探讨恶性血液病患者院感染的相关因素及处理。方法采用回顾性调查方法,对546例恶性血液病患者进行调查分析。结果 546例患者中并发医院感染者178例,感染率32.7%。感染部位以呼吸系统为主。致病菌G（-）杆菌占59.5%,高于G（＋）球菌（35.4%）。住院时间长、白细胞数在2.0×109/L以下、原发病为急性白血病和多发性骨髓瘤的恶性血液病患者易发生医院感染。结论恶性血液病患者是医院感染的高危人群,应对病人进行保护性隔离,及时发现感染,合理使用抗感染药物,加强支持治疗。在抗感染药物治疗的基础上加用重组粒细胞集落刺激因子有助于提高抗感染的疗效。

Clinical analysis of hospital infection in hematologic malignancies patients

Objective To investigate the causes and measures of hospital infection in hematologic malignancy patients.Method The data of 546 hematologic malignancy patients were retrospectively analyzed.Results Among the 546 patients,178 cases had hospital infection with a rate of 32.7%.Most of the infected areas were respiratory system.Gram-negative bacilli accounted for 59.5%,higher than Gram-positive ball germ（35.4%）.hematologic malignancy patients who had long hospital stay,white cell count less than 2.0×109/L,primary disease of acute leukemia and multiple myeloma were particularly vulnerable to hospital infection.Conclusion hematologic malignancy patients are vulnerable to hospital infection and should be separated.Infections should be identified in time and reasonable anti-infection medicine should be administered to support treatment.Besides anti-infective agents,the use of recombinant granulocyte colony-stimulating factor can contribute to the curative effect.