| 原发性胼胝体坏死灶中Alzheimer细胞GFAP的免疫组织化学反应及其意义 |
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| 引用本文： | 叶诸榕,马国钧,吴爱娟.原发性胼胝体坏死灶中Alzheimer细胞GFAP的免疫组织化学反应及其意义[J].复旦学报(医学版),1988(6). |
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| 作者姓名： | 叶诸榕 马国钧 吴爱娟 |
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| 作者单位： | 上海医科大学基础医学部病理学教研室
(叶诸榕，马国钧)，上海医科大学基础医学部病理学教研室(吴爱娟) |
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| 摘 要： | 本文报道原发性胼胝体坏死灶中出现ALzhEimer Ⅰ型(AⅠ)和2型(AⅡ)细胞的胶质纤维酸性蛋白(GFAP)免疫组织化学染色反应。AⅠ细胞呈强阳性染色,AⅡ细胞呈阴性染色。讨论了非高血氨性脑病中AⅠ和AⅡ细胞的形成机理。结果提示AⅠ细胞的发生与星形胶质细胞反应性增生的密切关系,以及AⅡ细胞在其形成的早期比正常的星形胶质细胞有更高的分裂和增殖能力。
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| 关 键 词： | 原发性胼胝体坏死 Alzheimer Ⅰ型细胞 AlzheimerⅡ型细胞 胶质纤维酸性蛋白 |
THE REACTIVITY OF ALZHEIMER GLIA TO IMMUNOCHE-MICAL STAIN OF GFAP IN MARCHIAFAVA-BIGNAMIDISEASE AND ITS SIGNIFICANCE |
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| Ye Zhurong,Ma Guojun,Wu Aijuan.THE REACTIVITY OF ALZHEIMER GLIA TO IMMUNOCHE-MICAL STAIN OF GFAP IN MARCHIAFAVA-BIGNAMIDISEASE AND ITS SIGNIFICANCE[J].Fudan University Journal of Medical Sciences,1988(6). |
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| Authors: | Ye Zhurong Ma Guojun Wu Aijuan |
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| Abstract: | The immnnoreactivity of Alzheimer type I (AI) cells were strongly positive and type II (AII) cells negative to GFAP stain in Marchiafava-Bignami disease. The- cytogenesis of AI and A II cells in non-hepatic and non-hyperarnmonemic encophalopathy was discussed. Observations suggest: (1) a close interrelationship between the development of AI abnormality -and reactive astrogliosis, (2) the increase in the abiliiy of mitotic division of early A II cells in response to injury. |
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