Therapie von Hirnmetastasen und Meningeosis neoplastica

The continuous development of systemic chemotherapy of malignant tumors and the introduction of novel substances into the therapeutic regimen has not so far changed the therapeutic concept for cerebral metastases. Difficulties confounding the evaluation of these new substances are due to the fact that there are virtually no randomized studies which demonstrate the benefit of targeted therapies alone or in combination with other therapeutic modalities. The intention of this article is to review current data on the therapy of solid tumor brain metastases and to put them into relation to current therapeutic recommendations. Special emphasis is placed on the importance of multimodal concepts and the value of targeted therapies, as further development of therapeutic recommendations are to be expected in this field.