Type 1 diabetes,thyroid, gastric and adrenal humoral autoantibodies are present altogether in almost one third of adult celiac patients at diagnosis,with a higher frequency than children and adolescent celiac patients |
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| Authors: | Claudio Tiberti Francesca Panimolle Raffaele Borghini Monica Montuori Chiara Maria Trovato Tiziana Filardi |
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| Affiliation: | 1. Department of Experimental Medicine, “Sapienza” University of Rome, Rome, Italy;2. claudio.tiberti@uniroma1.it;4. Department of Internal Medicine and Clinical Specialties, “Sapienza” University of Rome, Rome, Italy;5. Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, “Sapienza” University of Rome, Rome, Italy |
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| Abstract: | ![]()
AbstractBackground: No data are available on the frequency of organ-specific humoral autoimmunity at diagnosis of adult celiac disease (CD).Aim: To evaluate the humoral immunoreactivities specific of type 1 diabetes (T1D), thyroid (THD), atrophic-gastritis (AG) and Addison’s (AD) diseases in 92 adult CD patients at diagnosis and 237 adult healthy subjects (CTRL).Methods: T1D, THD and AD specific autoantibodies were analyzed by radioimmunoprecipitation assays. AG autoantibodies were detected by enzyme-linked immunosorbent assay.Results: Of 92?CD patients, 31.5% were positive for at least one of the organ-specific autoantibodies investigated (p?Conclusions: One third of adult CD patients at diagnosis is target of at least one organ-specific autoantibody. A systematic organ-specific autoantibody screening in these patients might be of value to promptly identify, prevent or treat the relative diseases. |
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| Keywords: | Celiac disease organ-specific autoimmunity humoral autoimmunity |
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