Patient preferences and predicted relative uptake for targeted therapies in metastatic colorectal cancer: a discrete choice experiment |
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| Authors: | Xin Yi Wong Andrew Qi Jun Lim Qianyu Shen John Whay Kuang Chia Min Hoe Chew Wah Siew Tan |
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| Institution: | 1. Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore  https://orcid.org/0000-0002-5232-1864;2. NUS Science Research Programme, Hwa Chong Institution (College Section), Singapore, Republic of Singapore;3. Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore;4. Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore;5. Department of Colorectal Surgery, Singapore General Hospital, Singapore, Republic of Singapore |
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| Abstract: | Abstract Objective Ras wild-type metastatic colorectal cancers (mCRC) may be treated with anti-vascular endothelial growth factor (VEGF) or anti-epidermal growth factor receptor (EGFR) agents. We aim to estimate patients’ preferences for mCRC treatment and relative importance of cost, efficacy improvement, avoidance of side effects and therapy convenience, and relative uptake between profiles that resemble Bevacizumab (anti-VEGF) and Cetuximab (anti-EGFR), two commonly prescribed mCRC targeted therapies. |
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| Keywords: | Targeted therapy metastatic colorectal cancer discrete choice experiment patient preferences relative uptake |
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https://orcid.org/0000-0002-5232-1864;2. NUS Science Research Programme, Hwa Chong Institution (College Section), Singapore, Republic of Singapore;3. Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Republic of Singapore;4. Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Republic of Singapore;5. Department of Colorectal Surgery, Singapore General Hospital, Singapore, Republic of Singapore