支架治疗动脉硬化性肾动脉狭窄对肾功能影响的前瞻性研究

目的:探讨肾动脉支架置入术,对肾动脉狭窄导致缺血性肾病患者的肾功能影响。方法:2008年1月至2010年1月,对肾动脉狭窄合并有肾功能不全的患者,采用肾动脉支架进行血管腔内治疗。术后1,3,6及12个月定期复查血清肌酐水平。结果:共入选26例患者进行了肾动脉支架治疗,男性14例,女性12例,平均年龄(62±14)岁,术前肾血清肌酐水平为(151.58±11.86)umol/L,术后1个月血肌酐水平为(149.96±16.39)umol/L,与术前差异无统计学意义(P=0.551)。术后3,6及12个月肌酐分别为〔(140.38±27.07)umol/L,P=0.02〕,〔(137.15±30.73)umol/L,P=0.005〕,〔(135.38±33.37)umol/L,P=0.005〕,均低于术前水平,差异具有统计学意义。结论:肾动脉腔内支架成形术,可改善肾动脉狭窄患者的肾功能。

Prospective study on effect of stent placement in patients with arteriosclerotic renal artery stenosis on renal insufficiency

Objective:To explore the of endovascular treatment with stents of patients with stenosis of renal artery on improvement of renal dysfunction.Methods: Between January,2008 and January,2011,patients with renal artery stenosis and renal dysfunction were randomly selected for stenting of stenostic renal artery.Levels of serum creatinine was examined before procedure and during follow-up at 1,3,6,12 months.Results: Twenty six patients underwent stent placement including 14 male and 12 females,with average age of(62±14)years.Level of serum creatinine was(151.58±11.86)umol/L before treatment.All patients followed for one years,with circulation level of creatitine of(149.96±16.39)umol/L,((140.38±27.07)umol/L,P=0.02)),((137.15±30.73)umol/L,P=0.005),((135.38±33.37)umol/L,P=0.005) at 1,3,6,12 months.Level of serum creatinine at 3,6,12 months was significantly lower than that before procedure Conclusion:Endovascular treatment of stenting of stenotic renal artery could improve the renal function.