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| 中国人VKORC1基因多态性对华法林维持剂量影响的Meta分析 | |
| 引用本文： | 鲁晓春,李世英. 中国人VKORC1基因多态性对华法林维持剂量影响的Meta分析[J]. 心肺血管病杂志, 2012, 31(3): 259-263 |
| 作者姓名： | 鲁晓春 李世英 |
| 作者单位： | 1. 100853,解放军总医院心血管一科 2. 首都医科大学附属北京安贞医院-北京心肺血管疾病研究所心内科28病房 |
| 摘 要： | 目的:分析中国人VKROC1基因多态性对华法林维持剂量的影响。方法:检索2000年至2011年6月相关中、英文数据库,用Stata10.0软件进行Meta分析。结果:共纳入22项研究(共3 449人),中国人VKROC1各基因型频率为AA型比例为80.4%,AG型17.8%,GG型1.8%。与AA型相比,AG型华法林维持剂量较AA增加40.8%(95%CI 36.5～55),纯合GG型较AA型增加84.2%(95%CI:47.7～120.8),2种合并AG+GG型较AA型增加51.7%(95%CI:39.6～63.8)。按剂量要求GG型>AG型>AA型。结论:中国人VKROC1基因多态性频率与其他种族不同,对华法林维持剂量具有重要影响。 |
| 关 键 词： | 华法林 VKROC1 基因多态性 Meta分析 中国人 |
Influence of VKROC1 genetic polymorphism on warfarin dosage requirement in Chinese populations: A Meta-analysis |
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| LU Xiaochun , LI Shiying. Influence of VKROC1 genetic polymorphism on warfarin dosage requirement in Chinese populations: A Meta-analysis[J]. Journal of Cardiovascular and Pulmonary Diseases, 2012, 31(3): 259-263 | |
| Authors: | LU Xiaochun LI Shiying |
| Affiliation: | Department of Nanlou Cardiology 1,PLA General Hospital,Beijing 100853,China |
| Abstract: | Objective:To evaluate the impact of VKROC1 genetic polymorphism on warfarin dosage requirement in Chinese populations.Methods:Related databases were searched,studies from 2000 to June 2011 were researched and Meta-analysis was performed using Stata 10 software.Results:Total 22 articles(3 449 patients) were included in this meta-analysis.The VKROC1 alleles in Chinese frequencies were difference from other population groups.Compared with VKROC1 AA group,warfarin dosage requirement in AG group,GG group and AG+GG group increased about 40.8%(95% CI 36.5-55.0),84.2%(95% CI 47.7-120.8) and 51.7%(95% CI: 39.6-63.8).Conclusion:The VKROC1 allele in Chinese frequencies were difference from other racial population,and there is difference in the requirement of warfarin dosage. |
| Keywords: | Warfarin VKROC1 Genetic polymorphism Meta-analysis Chinese |
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