| 阿司匹林铜对沙土鼠脑缺血损伤的保护作用 |
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| 引用本文： | 吴春云,李玲.阿司匹林铜对沙土鼠脑缺血损伤的保护作用[J].昆明医学院学报,1997,18(3):14-17. |
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| 作者姓名： | 吴春云 李玲 |
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| 作者单位： | 昆明医学院组胚教研室，昆明医学院，云南省天然药物重点实验室，昆明贵金属研究所 |
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| 基金项目： | 云南省应用基础研究基金 |
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| 摘 要： | 采用沙土鼠双侧颈总动脉夹闭１０ｍｉｎ或２０ｍｉｎ后再灌７ｄ或１ｄ，造成脑缺血再灌损伤模型，观察阿司匹林铜对沙土鼠脑组织钙、水含量的影响，及对海马ＣＡ１区神经元迟发性损伤的保护作用．结果显示：阿司匹林铜（７．５ｍｇ／ｋｇ）即能减轻脑组织钙累积，剂量１５ｍｇ／ｋｇ能增加脑缺血后海马ＣＡＩ区的神经元密度．提示阿司匹林铜对缺血再灌脑组织损伤有一定的保护作用．
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| 关 键 词： | 阿司匹林铜，脑缺血，再灌，钙，神经元密度，沙土鼠 |
Neuroprotective Effects of Copper Aspirin on Cerebral Ischemia Injury in Gerbils |
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| Wu Chunyun,Li Ling,Guao Zeyun,Chen Zhihe,Liu Weiping,Yang Yikun.Neuroprotective Effects of Copper Aspirin on Cerebral Ischemia Injury in Gerbils[J].Journal of Kunming Medical College,1997,18(3):14-17. |
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| Authors: | Wu Chunyun Li Ling Guao Zeyun Chen Zhihe Liu Weiping Yang Yikun |
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| Institution: | Wu Chunyun 1) Li Ling 2) Guao Zeyun 1) Chen Zhihe 2) Liu Weiping 3) Yang Yikun 3) |
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| Abstract: | Cerebral ischemia injury model was produced by 10 min or 20 min occlusion of bilateral carotid arteries followed by 7 d or 1 d reperfusion in gerbils. Copper aspirin was observed for its effects on calcium and water contents in gerbil brain cortex and on protection from neuronally delayed injury in hippocamal CA 1 sector. The results indicated that copper aspirin (7 5 mg/kg) could reduce the calcium accumulation in brain cortex and that the dosage of 15 mg/kg could increase neural density in the posterior CA 1 sector of hippocampus. All this suggested that copper aspirin has neuroprotective effects on cerebral ischemia reperfusion injury. |
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| Keywords: | Copper aspirin Cerebral ischemia Reperfusion Neuronal density Gerbils |
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