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Arginine depletion in macrophage medium inhibits collagen synthesis by fibroblasts
Authors:M. Jalkanen  H. Larjava  J. Heino  T. Vihersaari  J. Peltonen  R. Penttinen
Affiliation:Department of Medical Chemistry, University of Turku, Künamyllynk 10, SF-20520 Turku 52, Finland
Abstract:In the present work we demonstrate that non-activated, cultured rat peritoneal macrophages deplete arginine from their culture medium and that the use of this medium in fibroblast cultures may lead to decreased synthesis of collagen by fibroblasts.
Keywords:HSV-1  athymic mice  neutralizing antibodies  latency
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