Suppression of humoral and cellular immunity in normal mice by diazepam |
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| Authors: | Jacques Descotes Rosine Tedone Jean Claude Evreux |
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| Affiliation: | Laboratoire de Pharmacologie, Faculté de Médecine Alexis Carrel, rue G. Paradin, 69 008 Lyon, France |
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| Abstract: | ![]()
Diazepam, a benzodiazepine derivative useful in the treatment of anxiety disorders, was found to depress both primary antibody to sheep red blood cells and delayed-type hypersensitivity responses in normal mice. This immunodepressant activity warrants further investigation owing to its potential consequences on human health and the putative involvement of specific receptors on immunocompetent cells. |
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| Keywords: | diazepam immunosuppression in vivo humoral immunity in vivo cellular immunity normal mice |
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