可溶性致癌抑制因子2与老年急性心肌梗死患者心功能关系的探讨

目的：探讨老年急性心肌梗死（AMI）患者血清可溶性致癌抑制因子2（sST2）与其心功能之间关系。方法选取年龄＞60岁、发病24h内的AMI患者59例，来诊后立即测定N端脑钠肽前体（NT-proBNP）、sST2，进行Killip心功能分级，48h内完成超声心动图检查。设立36例年龄匹配的健康对照检测sST2。结果 sST2在AMI组较对照组明显升高（36.2±21.3） vs （12.5±11.4）μg/L，P＜0.05]；AMI组中sST2和NT-proBNP有明显正相关性（r＝0.585，P＜0.05）；sST2和左心室射血分数（LVEF）表现出明显负相关（r＝-0.611，P＜0.05）；sST2在KillipⅠ级和Ⅱ级（27.6±14.5） vs （38.0±20.6）μg/L，P＜0.05]，Ⅱ级和Ⅲ＋Ⅳ级间差异显著（56.5±25.0）μg/L， P＜0.05]。结论 AMI患者中sST2较对照组明显升高，且与NT-proBNP和LVEF有相关性，sST2随Killip分级级别升高有上升趋势，而NT-proBNP无此趋势。

Relationship of serum soluble suppression of tumorigenicity 2 with cardiac function in elderly patients with acute myocardial infarction

Objective To evaluate the relationship of serum level of soluble suppression of tumorigenicity 2（sST2） with cardiac function in the elderly patients with acute myocardial infarction （AMI）. Methods A total of 59 patients （≥60 years） with AMI within 24 h of symptom onset admitted in our department from March to December 2011 were subjected in this study. Immediately after admission, their serum levels of sST2 and N-terminal pro-brain natriuretic peptide （NT-proBNP） were measured, Killip cardiac function class was analyzed, and echocardiography was performed within 48 h. Another 36 age-matched healthy subjects were recruited as normal controls. Results The serum level of sST2 was significantly higher in AMI patients than in control group （36.2±21.3） vs （12.5±11.4）μg/L, P〈0.05]. In the AMI group, the sST2 level was positively correlated with NT-proBNP level （r=0.585, P〈0.05）, and negatively correlated with left ventricular ejection fraction （LVEF） （r=-0.611, P〈0.05）. Significant differences were seen in sST2 level between Killip Ⅰ and Ⅱ （27.6±14.5） vs （38.0±20.6） μg/L, P〈0.05] and between Killip Ⅱ and Ⅲ＋Ⅳ （56.5±25.0）μg/L, P〈0.05]. Conclusion The serum level of sST2 is significantly higher in AMI patients than in normal controls. The sST2 level is correlated with NT-proBNP level and LVEF, and also, in an increasing trend with the elevation of Killip grading, but NT-proBNP level has no such trend.