Bcl-2基因、雌激素受体和孕酮受体在子宫内膜的表达

目的 探讨bcl-2、雌激素受体（ER）和孕酮受体（PR）在子宫肌层、卵巢、输卵管壁的异位内膜与子宫正位内膜的表达及春意义。方法 用免疫组化S－P法对子宫肌层内的异位内膜15例，卵巢内膜异位15例，输卵管壁内膜异位5例及子宫正位内膜25例进行bcl-2、ER和PR检测。结果 bcl-2在子宫肌层内和输卵管内的异们丙膜阳性表达率为100％，卵巢异位内膜阳性表达率为86．6％，子宫正位内膜阳性表达率为52％。ER在子宫肌层的内膜异位阳性表达率为6．7％，卵巢内膜异位为33．0％，而4例输卵管内膜异位无阳性表达。PR在子宫肌层有内膜异位阳性表达率为86．6％，卵巢内膜异位为20．0％，5例输卵管内膜异位均表达阳性。结论 异位的子宫内膜细胞凋亡明显少于正位内膜，细胞生长有一定活跃性。异位子宫内膜的增生、分泌与正位子宫内膜不同步，表现为不规则性。卵巢、输卵管异位内膜的发生，可能与原始间叶细胞异分化有关。

Expressions of Bcl-2,estrogen receptor(ER)and progesterone receptor(PR) in endometriosis and eutopic endometrium

Objective To explore the expressions of bcl 2,ER and PR in ectopic endometrium of myometrium,ovary,uterine tube and eutopic endometrium. Methods The expressions of bcl 2,ER and PR in 15 cases of ectopic endometrium of myometium,15 cases of ectopic endometrium of ovary,5 cases of ectopic endometrium of uterine tube and 25 cases of eutopic endometrium were detected by immunohistochemical S P method. Results The positive rate of bcl 2 expression in ectopic endometriosis of myometrium,uterine tube and ovary was 100%, 100% and 86.6%, respectively;while the positive rate of bcl 2 expression was 52%. The positive rate of ER expression ectopic endometrium of myometrium and ovary was 6.7% and 33.0%,respectively; while there was no positive expression in 5 case of uterine tube. The positive rate of PR expression in ectopic endometrium of myometrium and ovary was 86.6% and 20.0%,respectively;while there was positive expression in all of the cases of uterine tube. Conclusion The apoptosis of endometriotic cells were less than that of eutopic endometrium significantly.The proliferation and secretion of ectopic endometrioum and eutopic endometrium were out of step.Endometriosis of ovary and fallopian tube may be ralated to heterodifferentiation of primitive mesenchymal cell.