Immunoprofile of the adenomatoid odontogenic tumor |
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| Authors: | PA Reichart HP Philipsen P Khongkhunthian JJ Sciubba |
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| Affiliation: | 1. Department of Oral Medicine, Dental Radiology and Oral Surgery, CC03, Charité‐Universitaetsmedizin Berlin, Berlin, Germany;2. Retired;3. Faculty of Dentistry, Center of Excellence for Dental Implantology, Chiang Mai University, Chiang Mai, Thailand;4. The 5. Milton J. Dance Head and Neck Center, The Greater Baltimore Medical Center, Baltimore, USA |
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| Abstract: | ![]()
This study was focused on the immunohistochemical profile of the adenomatoid odontogenic tumor. A Pub/Medline search revealed a number of immunohistochemical studies including cytokeratin profiles, extracellular matrix proteins, Integrins, ameloblast‐associated proteins resorption regulators (RANK, RANKL), p53, PCNA, MDM2 protein, cyclin D1, Ki‐67, Bcl‐2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c‐met, DNA methyltransferase, podoplanin, TGF‐βI, Smad‐2/3, Smad‐I‐5/‐8, Smad 4, beta‐ catenin, calretinin, and clonality. Careful interpretation of the findings indicates that the adenomatoid odontogenic tumor may be more of a hamartomatous than neoplastic nature. |
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| Keywords: | immunohistochemistry hamartoma neoplasm adenomatoid odontogenic tumor |
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