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| p15蛋白在骨肉瘤中表达的研究 | |
| 引用本文： | 韩壮,西中海,华凯,何忠野,吕刚,陈铁. p15蛋白在骨肉瘤中表达的研究[J]. 中国医科大学学报, 2003, 32(1): 54-55 |
| 作者姓名： | 韩壮 西中海 华凯 何忠野 吕刚 陈铁 |
| 作者单位： | 1. 中国医科大学附属第一医院骨科,辽宁,沈阳,110001 2. 营口市中心医院骨科 3. 辽宁省人民医院骨科 4. 沈阳市第一人民医院外科 5. 沈阳机车车辆厂医院 |
| 摘 要： | 目的:研究p15蛋白在骨肉瘤中的表达,探讨其表达与骨肉瘤的相关性。方法:采用S-P免疫组化方法,检测22例骨肉瘤中p15的表达;结果:p15蛋白在22例骨肉瘤中表达的阳性率为54.5％,而20例骨软骨瘤中阳性率为15.0％。骨肉瘤p15蛋白表达与骨软骨瘤相比差异具有统计学意义(x2=7.13,P<0.01)。结论:p15蛋白的表达与肿瘤的恶性度相关,与骨肉瘤的发生、发展具有相关性。 |
| 关 键 词： | 骨肉瘤 p15蛋白 免疫组化方法 |
| 文章编号： | 0258-4646(2003)01-0054-02 |
| 修稿时间： | 2002-05-10 |
Expression of p15 protein in Osteosarcoma |
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| HAN Zhuang,XI Zhong-hai,HUA Kai,HE Zhong-ye,LU Gang,CHEN Tie. Expression of p15 protein in Osteosarcoma[J]. Journal of China Medical University, 2003, 32(1): 54-55 | |
| Authors: | HAN Zhuang XI Zhong-hai HUA Kai HE Zhong-ye LU Gang CHEN Tie |
| Abstract: | Objective: Our aims were to study the expression of p15 protein in osteosarcoma and to investigate the function of p15 protein in carcinogenesis and development of osteosarcoma. Methods: We detected p15 protein in 22 cases of osteosarcoma, and immunohistological method was used. Results: The positive rate of p15 protein in 22 cases of osteosarcoma in this study was 54. 5% ,and 15. 0% in 20 cases of osteochondroma. Significant difference can be seen between osteosarcoma and osteochondroma. Conclusion: The expression of p15 protein was relevant to histological type, and may be associated with carcinogenesis and development of osteosarcoma. |
| Keywords: | osteosarcoma p15 protein immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |